This new discovery as reported in The American Journal of Human Genetics, adds to scientific understanding of the causes of sudden cardiac death and of possible ways to prevent it.
“We have observed that NOS1AP genetic variants are associated with sudden cardiac death, raising the risk by about 40%...and 67% of the general population carries the NOS1AP-overproducing genetic variant”
Dr Ashish Kapoor, Ph.D., a postdoctoral researcher, May 2014.
“Traditionally, geneticists have studied gene variants that cause disease by producing an abnormal protein. We think there will turn out to be many DNA variants that, like this one, cause disease by making too much or too little of a normal protein”
Aravinda Chakravarti, a professor of medicine, pediatrics, molecular biology and genetics, and biostatistics in the McKusick-Nathans Institute of Genetic Medicine at the Johns Hopkins University School of Medicine, May 2014.
As reported by biosciencetechnology.com on Wednesday 28 May, 2014.