Smoking by grandmother could be the cause of grandchild's Asthma
Epigenetics tells us about the incredible effect your diet, lifestyle and environment have on your genetic expression – even two generations later.
Epigenetic modification is when an environmental factor causes a genetic change, such as when you smoke, you get sick - regardless of your genetics.
Researchers have found that pregnant rats given nicotine produced asthmatic pups that then produced their own asthmatic pups - despite no exposure to nicotine in the third generation. This shows genetic damage that is passed down from parent to grandchild. This is not inherently genetic though as it is caused initially by environment and lifestyle choices. Choices like do I smoke or not? These are further findings showing that inheritable epigenetic markers on your genome can make your children and grandchildren more susceptible to disease.
The Children’s Health Study from Southern California has also found that if your grandmother smoked during pregnancy then the incidence of asthma in the grandchildren increases regardless of whether mum smoked or not.
This further confirmation of multi-generational transmission of disease suggests the diet; lifestyle and environment that you choose in your life, and your grandparents chose in their lives, will either strengthen or weaken you, and your ancestors.
“These studies break new ground in validating and further explaining the mechanisms involved in the transmission of epigenetic human diseases. The transmission of the asthma to the second generation and its prevention by a specifically-targeted molecular intervention are the first unequivocal demonstrations of multi-generational transmission of an epigenetically-mediated effect on the offspring. This multi-generational transmission could explain why 98% of inherited human diseases are unaccounted for by the prevailing view of genetic trait transmission…”
John S. Torday, PhD, Los Angeles Biomedical Research Institute.
Study by Los Angeles Biomedical Research Institute (LA BioMed) lead researchers John S. Torday, PhD, and Virender K. Rehan, MD, as published in the March 2013 edition of Review of Obstetrics & Gynecology. As reported by sciencedaily on March 4, 2013.