Cholesterol increases risk of Alzheimer's and heart disease

Cholesterol increases risk of Alzheimer’s and heart disease

“High levels of blood cholesterol increase the risk of both Alzheimer’s disease and heart disease, but it has been unclear exactly how cholesterol damages the brain to promote Alzheimer's disease and blood vessels to promote atherosclerosis”

“Identifying the specific problem caused by cholesterol will lead to completely new approaches to therapy for many human diseases, including Alzheimer’s disease, atherosclerosis and possibly cancer, all of which show signs of defective cell division”
Science Daily, April 2013.

I have a suggestion - cut back on red meat.  Over consumption of red meat is associated with a higher incidence of both heart disease and cancer”  
Dr. Stephen Sinatra, co-author The Great Cholesterol Myth.

What have health researchers clarified about cholesterol?

  • High blood levels of LDL ‘bad’ cholesterol causes havoc on healthy cell division
  • This leads to an accumulation of defective daughter cells reproducing with the wrong number of chromosomes - and crucially - the wrong number of genes
  • Instead of the correct 2 copies of each chromosome, and 2 copies of each gene, some cells acquire three copies and some only one
  • As many as 10% of cells in an Alzheimer patient, including neurons in the brain, have three copies of chromosome 21 instead of the usual two
  • This single mechanism may underlie the damaging effect of cholesterol on the brain and on blood vessels
  • They found cells carrying three copies of the chromosome “Human trisomy 21”, that encodes the amyloid peptide that is the key component of the neurotoxic amyloid filaments that accumulate in the brains of Alzheimer patients, causing damage
  • Trisomy 21 is significant because those with Down syndrome have trisomy 21 in all of their cells from the moment of conception
  • Those with Down syndrome all develop the brain pathology and many develop Alzheimer’s disease by age 50
  • The mutant genes that cause inherited Alzheimer’s disease cause the same defect in chromosome segregation - as does cholesterol
  • This shows that regardless of family history or genetics, there is a common cell division problem

Study by Antoneta Granic, PhD, and Huntington Potter, PhD, researchers at the Linda Crnic Institute for Down Syndrome, and the Department of Neurology of the University of Colorado School of Medicine, as published April 15, 2013 in the on-line journal PLOS ONE.  As reported by sciencedaily.com on April 15, 2013 and by ANI on April 16, 2013.

Full article here: http://www.sciencedaily.com/releases/2013/04/130415182507.htm

 

Posted: Saturday 20 April 2013

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