Heart failure due to a protein 'misbehaving'

Heart failure due to a protein ‘misbehaving’

The proteins in your diet – and where they come from – dictate your heart health.

With heart failure, the cardiac protein troponin I (found exclusively in the heart muscle), changes, and loses its ability to regulate heart relaxation or contraction.  This is famously known as the fight or flight response.  Instead, troponin I subtly modulates cardiac muscle function and reduces the heart’s ability to pump efficiently, leading to heart failure.

“Right now, we don’t really know which heart attacks patients will develop heart failure and which ones will maintain normal heart muscle function”
Senior Investigator Anne Murphy, M.D., Cardiologist at Johns Hopkins Children’s Center.

“Disease often has to do with producing the right amount of protein at the right place at the right time.  Changing the amount of a protein will also create disease”
Aravinda Chakravarti, Molecular Geneticist, John Hopkins Medicine.

Could the solution to saving lives from heart failure be simply diet and lifestyle changes?

Study from Johns Hopkins as published online ahead of print on September 12, 2012 in the journal Circulation.


Posted: Wednesday 27 March 2013