Too much cooked food raises obesity and diabetes risk

Too much cooked food raises obesity and diabetes risk

More bad news on the effects of too much cooked and processed food in your diet.  I recommend a healthy balance of raw foods, sprouted foods, fermented foods and cooked foods.

Helen Vlassara, MD, Professor and Director of the Division of Experimental Diabetes and Aging, and colleagues, found that mice with sustained exposure to the advanced glycation endproduct (AGEs) compound, methyl-glyoxal (MG), developed significant abdominal weight gain, early insulin resistance, and type II diabetes. 

AGEs are created when foods are highly processed, cooked at too high a temperature, or on a dry heat for too long.  AGEs have been shown many times now in clinical studies to raise the risk of non-communicable diseases such as cancer, diabetes, obesity and heart disease.  They lower the body’s protective mechanisms that control inflammation.

What did the study find?

  • Mice fed a diet high in MG over four generations, developed insulin resistance and increased body fat
  • Mice on a normal diet did not have either of these conditions
  • The MG enhanced the metabolism of glucose and insulin
  • The MG caused a marked deficiency in protective mechanisms, such as the survival factor SIRT1 that is present in fat and controls inflammation
  • The MG affected the activity of an important anti-AGE receptor called AGER1, which protects SIRT1 and fights insulin resistance
  • Mice that were fed the low-in-MG diet displayed high levels of SIRT1, AGER1 and no diabetes

Study by researchers at Mount Sinai School of Medicine as published in the Proceedings of the National Academy of Sciences, 2012.  Helen Vlassara, MD, Professor and Director of the Division of Experimental Diabetes and Aging, and colleagues, found that mice with sustained exposure to the advanced glycation endproduct (AGEs) compound, methyl-glyoxal (MG), developed significant abdominal weight gain, early insulin resistance, and type II diabetes.  The mice without this exposure did not get any diseases.  As reported by The Times of India on August 21, 2012.

Posted: Friday 18 January 2013

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