Alzheimer's markers seen years before symptoms

Alzheimer’s markers seen years before symptoms

There are many lifestyle diseases now – also known as non-communicable diseases as they are not spread by touch or breathe.  Alzheimer’s is now seen as another disease of affluence and lifestyle with signs showing up years before diagnosis.

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The researchers said “Our findings indicate the Alzheimer’s disease process begins more than 20 years before the clinical onset of dementia”. 

Randall Bateman, MD, of Washington University in St. Louis, and colleagues found Beta amyloid protein measurements may begin to show abnormalities more than 25 years before overt symptoms of Alzheimer’s are seen.  In addition, beta amyloid plaques could be imaged in patients’ brains some 15 years before expected symptom onset. 

The results come from DIAN, the Dominantly Inherited Alzheimer Network (analyzed data on 128 DIAN participants, including 88 who carried the Alzheimer-associated mutations in the PSEN1, PSEN2, and/or APP genes). 

Murali Doraiswamy, MD, of Duke University, said “The DIAN study is poised to become the road map for all Alzheimer’s disease diagnostic and treatment studies over the next 10 years”

Study by Bateman R, et al “Clinical and biomarker changes in dominantly inherited Alzheimer’s disease” as published in the New England Journal of Medicine 2012; DOI:10.1056/NEJMoa202753.  The National Institute on Aging funded the study.  As reported by MedPage Today on July 12, 2012.

Posted: Friday 24 August 2012

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